Neutrophil Transfusion: Effect ofStorage and ofCollection Method on Neutrophil Blood Kinetics

The kinetics in blood of autologous neuin whole blood for 1-2 days, posttransfutrophils collected by phlebotomy, filtration sian recoveries and blood half-times were leukapheresis (FL), or intermittent-flow significantly decreased. Storage of both centrifugation (IFC), labeled with 32PIFC and FL preparations resulted in only diisopropylfluorophosphate, and stored at moderate kinetic abnormalities in corn4#{176}C for up to 2 days were measured in 41 parison to the unstored cells. These studies normal subjects. Mean initial recovery for indicate that the ability of unstored IFC unstored IFC cells was 34.0%, compared cells to circulate is basically normal, to 7.9% for unstored FL cells. Blood halfwhereas that of unstored FL cells is signifilives were 4.1 and 2.7 hr for unstored cantly impaired. The data further suggest IFC and FL cells, respectively. With neutrothat these neutrophil concentrates might phils collected by phlebotomy and stored be stored for 1-2 days prior to transfusion.